Updated September 25, 2026. Fact-checked against veterinary sources; review by a licensed veterinarian is in progress. See our editorial policy.
Quick answer: Of the supplements marketed for inflammation in cats, omega-3 fatty acids have the best evidence, with some benefit for arthritis and skin conditions. Evidence for glucosamine and chondroitin in cats is limited, and green-lipped mussel has some early supportive data. Cats are especially sensitive to many compounds, so human supplements and plant products like turmeric, essential oils, and alpha-lipoic acid should only be used with a vet’s approval, and some are toxic.
Supplements with some evidence
- Omega-3 fatty acids (fish oil), in amounts your vet recommends
- Green-lipped mussel extract
- Joint diets with added omega-3s
Limited or unclear evidence
- Glucosamine and chondroitin
- Turmeric and curcumin (limited cat-specific safety data)
- CBD products (unregulated, variable quality)
Avoid
- Alpha-lipoic acid, toxic to cats at low doses
- Essential oils
- Human pain relievers: acetaminophen is deadly, and aspirin and ibuprofen are dangerous
- Human multi-ingredient supplements
Treatments that help more
- Frunevetmab (Solensia) for arthritis pain
- Anti-inflammatory medications approved for cats, used under supervision
- Weight management and home changes
More: pain medication for older cats.
Sources
- Merck Veterinary Manual: Osteoarthritis in cats
- Hill AS, et al. Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats. J Anim Physiol Anim Nutr. 2004
- Monteiro BP, et al. 2022 WSAVA guidelines for the recognition, assessment and treatment of pain. J Small Anim Pract. 2022
This article is for general education and is not a substitute for care from your own veterinarian. Learn about The Pet Vet and our editorial policy.