Updated September 25, 2026. Fact-checked against veterinary sources; review by a licensed veterinarian is in progress. See our editorial policy.
Quick answer: Revolution Plus is a monthly prescription topical for cats containing selamectin and sarolaner. It’s labeled to kill fleas and certain ticks, treat ear mites, prevent heartworm disease, and treat roundworms and hookworms. Because it covers several parasites in one monthly dose, it’s a common choice. Your vet can help decide if it suits your cat.
What it covers
- Fleas
- Certain ticks
- Ear mites
- Heartworm prevention
- Roundworms and hookworms
It isn’t labeled for tapeworms, which cats get from fleas or hunting. Your vet may add a tapeworm treatment if needed.
Safety considerations
- Prescription only. Follow label age and weight minimums
- Sarolaner is an isoxazoline. The FDA has noted this class can be associated with neurological reactions such as tremors or seizures in some animals. Tell your vet about any seizure history
- Possible side effects include vomiting and hair loss or irritation at the application site
Alternatives
- Bravecto Topical or Bravecto Plus for Cats (longer-lasting)
- Revolution (selamectin alone), which covers fleas, ear mites, heartworm, and some worms, but has more limited tick coverage
- Other monthly combination products
Choosing
Consider indoor/outdoor lifestyle, local tick and heartworm risk, your cat’s health history, and which schedule you can keep. Apply to the skin at the base of the skull where your cat can’t lick.
Sources
- Zoetis: Revolution Plus (selamectin and sarolaner topical solution) product label
- US FDA: Fact sheet for pet owners and veterinarians about potential adverse events associated with isoxazoline flea and tick products
- American Heartworm Society: Feline heartworm guidelines
This article is for general education and is not a substitute for care from your own veterinarian. Learn about The Pet Vet and our editorial policy.