Updated September 25, 2026. Fact-checked against veterinary sources; review by a licensed veterinarian is in progress. See our editorial policy.
Quick answer: There’s no good evidence that routine vaccines cause liver disease in dogs. In fact, core vaccines protect against canine adenovirus (infectious canine hepatitis), and the leptospirosis vaccine protects against an infection that can damage the liver and kidneys. Liver problems are sometimes found at vaccine visits because that’s when bloodwork is done or signs are noticed.
How vaccines protect the liver
- Canine adenovirus-2 vaccine: part of the core DHPP vaccine, protects against infectious canine hepatitis
- Leptospirosis vaccine: recommended for many dogs, protects against a bacterial infection that can cause liver and kidney failure
Normal vaccine reactions
- Mild soreness, tiredness, or low fever for a day or two
When to call your vet
Call if your dog has vomiting, facial swelling, hives, weakness, or collapse after a vaccine (possible allergic reaction), or if you notice yellow gums or eyes at any time.
Dogs with liver disease
Dogs with liver disease can generally still be vaccinated. Your vet will tailor the schedule to your dog’s health.
Sources
- Ellis JA, et al. 2022 AAHA Canine Vaccination Guidelines. J Am Anim Hosp Assoc. 2022
- Sykes JE, et al. 2010 ACVIM small animal consensus statement on leptospirosis. J Vet Intern Med. 2011
- Merck Veterinary Manual: Infectious canine hepatitis
This article is for general education and is not a substitute for care from your own veterinarian. Learn about The Pet Vet and our editorial policy.